Plant-derived exosomes are emerging as a revolutionary ingredient in cosmetic skin care. These nanosized vesicles, secreted by plant stem cells, contain bioactive compounds such as proteins, peptides, lipids, nucleic acids, and secondary metabolites like polyphenols and flavonoids. Their unique ability to penetrate the skin and deliver these compounds makes them a powerful tool for addressing aging, hydration, and skin repair, offering a natural, sustainable alternative to traditional cosmetic ingredients. They are structurally like mammalian exosomes and its been shown that plant to human cross-kingdom communication is possible thanks to these exosomes, with plant based exosomic peptides and polyphenols influencing human skin cells in the same way they do with plant cells.
One of the primary advantages of exosomes is their exceptional transdermal delivery. Their lipid bilayer structure, similar to liposomes, allows them to penetrate the stratum corneum—the skin’s outermost barrier—through pathways like intercellular and transcellular routes.
Exosomes are highly effective in combating signs of aging. Natural exosomes are known to encapsulate and protect compounds of interest such as growth factors, proteins, peptides and signalling polyphenols which are all highly beneficial for skin regeneration.
Not all exosomes are equal. We have sourced the globe to eventually find one of the most reputable exosome suppliers in Europe who are ahead in this field and not only quantify their exosomes but also characterise the exosome content and source engineer their exosomes to form exosomes with an increased cargo load and thus enhanced exosomes. They have performed clinical studies in vitro and in vivo to support the effects of their exosomes. We believe these are the best plant based exosomes currently available.We use:
(1) Centella Reversa exosomes can reverse cellular senescence with powerful regenerative and well-ageing effects due to the presence of over 10,000 peptides and 1,000 proteins. It is believed that the synergy of these peptides is what makes it so effective. These exosomes have been tested on human fibroblast cells for their ability to stimulate pro-collagen and elastin production (key proteins for skin firmness and elasticity) and were compared to several industry standard peptides such as Matrixyl, EGF (epidermal growth factor) and IGF (insulin like growth factor) and were found to be significantly more effective than the standard peptides!
(2) Vitis Vinifera is able to trigger a hormetic response in the cell that has a fasting mimiking effect on skin cells. The benefit of this include: induces autophagy, protects against cellular senescence, protects against inflammation, reduces reactive oxygen species, to name a few benefits.
